A Spanish top-flight game will be played in the US, the first time a La Liga match has taken place overseas.
The plan is part of a 15-year partnership between La Liga and media company Relevent, which organises the International Champions Cup, to promote football in North America.
La Liga president Javier Tebas called it a “ground-breaking agreement”.
The Premier League has previously discussed plans to play a ’39th game’ outside England and Wales.
But executive chairman Richard Scudamore, who proposed the idea in 2008, said it could not happen “until the conditions are right”.
On Sunday, the Spanish Super Cup was played in Morocco, the first time it has been played outside Spain.
“This extraordinary joint venture is the next giant leap in growing soccer’s popularity in North America,” said Stephen Ross, chairman and owner of Relevent.
“This unique relationship will create new opportunities for millions of North American soccer fans to experience the most passionate, exciting, and highest level of soccer in the world.”
No timescale has been given for the introduction of the US-based fixture.