Workington will host Siddal in the third round of the Challenge Cup.
The Cumbrian side are coached by five-time cup winner Leon Pryce and narrowly missed out on promotion to the Championship last season.
Elsewhere, Lock Lane’s win at Milford has earned them a trip to League One Oldham and there is an all-third tier tie as Doncaster host Coventry.
All 12 ties will take place over the weekend of 9-10 March, with BBC Sport streaming one game live.
The 14 Championship sides will enter the competition in round four, four Super League clubs – Leeds Rhinos, Hull KR, Salford Red Devils and London Broncos – join in the fifth and holders Catalans Dragons and the seven remaining top-flight sides come in at the last-16 stage.
French side Catalans beat Warrington Wolves at Wembley last August to become the first non-English team to lift the trophy.
Challenge Cup third-round draw
Keighley Cougars v Distington
Oldham v Lock Lane
Thatto Heath Crusaders v Rochdale Mayfield
Wigan St Judes v Haydock
Newcastle Thunder v West Wales Raiders
London Skolars v North Wales Crusaders
Hunslet v West Bowling
Workington v Siddal
York Acorn v Featherstone Lions
West Hull v Dewsbury Moor
Doncaster v Coventry Bears
Whitehaven v Wigan St Pats